Copper
Cancer: Copper may cause cancer
and tumor chemotherapy resistance
 Researchers found copper blood levels were
lower in patients without cancer. They state copper is
involved in the development of cancer. Analysis of
patients with breast cancer, colon cancer and lung cancer
showed that serum copper was higher in patients not
responding to chemotherapy compared to patients whose
tumors responded to chemotherapy treatment. Additional research has
identified the cellular ATP7A and ATP7B related drug transport
systems as the source of copper induced cancer tumor resistance
to chemotherapy.
An extreme
deficiency or excess of any nutrient in our body, including
water will cause a health problem. The essential nutrient
copper is not any different. It is required for many
processes in the body. A deficiency is life
threatening. An excess increases the
risk of cancer, atherosclerosis, oxidative
damage, Alzheimer’s, Parkinson’s and a host of other
diseases. Sources of high amounts of copper include some
dietary supplements, drinking water, bath water and shower
water. A person with cancer should test their urine and blood
for copper. A Heavy Metal Screening
Test and Comprehensive
Urine Element Profile tests are available for home urine
testing. It’s difficult to get a doctor to order and find a
lab that can do a copper, ionized (free) copper and copper
bound to ceruloplasmin. The ionized copper is the most
difficult test to find.
Copper chelation
reduces the body’s production of tumor blood vessel growth
factors (angiogenesis) and reduces tumor growth
and small blood vessel density in animal studies. Human studies
of oral chelation drugs are currently underway.
Chelation should be
done with caution under guidance of a health care
professional. I know of one person that went into atrial
fibrillation due to magnesium deficiency caused by
unsupervised daily, oral, non-prescriptioni chelation.
Chelation products will bind and remove toxic metals
and essential minerals from your body, food and
supplements. You should monitor copper and mineral levels
and adjust dosages as indicated.
References
The role of copper in
drug-resistant murine and human tumors. Majumder S,
Chatterjee S, Pal S, Biswas J, Efferth T, Choudhuri SK.
Biometals. 2008 Oct
28.
Copper transport systems
are involved in multidrug resistance and drug
transport. Furukawa T, Komatsu M, Ikeda R, Tsujikawa K,
Akiyama S. Curr Med Chem.
2008;15(30):3268-78.
Pancytopenia complicated
with peripheral neuropathy due to copper deficiency:
clinical diagnostic review. Imataki O, Ohnishi H,
Kitanaka A, Kubota Y, Ishida T, Tanaka T.
Intern Med.
2008;47(23):2063-5
Induction of tumor cell
apoptosis by taurine Schiff base copper complex is
associated with the inhibition of proteasomal activity.
Zhang X, Bi C, Fan Y, Cui Q, Chen D, Xiao Y, Dou QP.
Int J Mol Med. 2008
Nov;22(5):677-82.
Serum zinc and copper
status in dyslipidaemic patients with and without
established coronary artery disease.Ghayour-Mobarhan M,
Taylor A, Kazemi-Bajestani SM, Lanham-New S, Lamb DJ,
Vaidya N, Livingstone C, Wang T, Ferns GA.
Clin Lab.
2008;54(9-10):321-9.
Mechanism of the
antioxidant to pro-oxidant switch in the behavior of
dehydroascorbate during LDL oxidation by copper(II)
ions. Horsley ET, Burkitt MJ, Jones CM, Patterson RA,
Harris LK, Moss NJ, del Rio JD, Leake DS.
Arch Biochem
Biophys. 2007 Sep 15;465(2):303-14.
Cellular lipid metabolism
is influenced by the coordination environment of
copper. Kennedy DC, Lyn RK, Pezacki JP.
J Am Chem Soc. 2009
Feb 25;131(7):2444-5.
Copper(II) binding to
alpha-synuclein, the Parkinson's protein. Lee JC, Gray
HB, Winkler JR. J Am Chem Soc. 2008
Jun 4;130(22):6898-9.
New strategy of
antiangiogenic therapy for hepatocellular carcinoma. Wu
XZ. Neoplasma.
2008;55(6):472-81
Phase
I study of copper-binding agent ATN-224 in
patients with advanced solid
tumors.Lowndes SA, Adams A, Timms A,
Fisher N, Smythe J, Watt SM, Joel S, Donate F,
Hayward C, Reich S, Middleton M, Mazar A, Harris
AL. Clin Cancer
Res. 2008 Nov
15;14(22):7526-34.
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