Arsenic Toxicity and Arsenic
Poisoning:
Arsenic is absorbed from drinking and
eating food cooked in contaminated water and through the
skin.
According to the
Centers for Disease Control (CDC) and Environmental
Protection Agency (EPA) potential side effects of low dose
long term exposure to Arsenic include:

|
Nausea
|
Vomiting
|
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Stomach
pain
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Diarrhea
|
|
Kidney
damage
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Diabetes
|
|
Liver
damage
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Abnormal
heart rhythm
|
|
Birth defects
|
Spontaneous
abortions
|
|
Cardiovascular
disease
|
Reproductive
problems
|
|
Darkening
of the skin
|
Lower
IQ levels in children
|
|
Partial paralysis
|
Blindness
|
|
Low
platelet count
|
Numbness
of hands and feet
|
|
Damage
to blood vessels
|
Decreased
red blood cell count
|
|
Decreased
white blood cell count
|
“corns”
or “warts” on the palms, soles and
torso
|
|
Sensation
of pins and needles in hands and feet
(neuropathy)
|
Thickening,
redness, itching, rash or swelling of the
skin
|
Long term arsenic toxicity and
arsenic poisoning increases the risk of several
cancers including:
|
Skin
cancer
|
Lung
cancer
|
Liver
cancer
|
|
Bladder
cancer
|
Kidney
cancer
|
Nasal
passage cancer
|
|
Prostate
cancer
|
|
|
The Department of Health and Human Services
(DHHS), International Agency for Research on Cancer
(IARC) and the EPA have determined that inorganic arsenic
toxicity is a known human carcinogen.
High dose, short term, exposure to Arsenic will cause
death.
Arsenic is a naturally occurring element widely distributed in
the earth’s crust. It is odorless and tasteless. It enters
drinking water supplies from natural deposits in the earth or
from agricultural (runoff from
orchards)
and industrial practices (runoff from glass &
electronic production wastes
).
Arsenic was used in pressure treated
chromated
copper arsenate (CCA) wood prior to December 31,
2003.
Arsenic is absorbed from drinking and eating food cooked in
contaminated water and through the skin.
There is some evidence that inhaled or ingested
arsenic can injure pregnant women or their unborn babies,
although the studies are not definitive. Studies in
animals show that large doses of arsenic that cause
illness in pregnant females, can also cause low birth
weight, fetal malformations, and even fetal death.
Arsenic can cross the placenta and has been found in
fetal tissues. Arsenic is found at low levels in breast
milk.
There is some evidence that long-term exposure
to arsenic in children may result in lower IQ scores.
There is also some evidence that exposure to arsenic in
the womb and early childhood may increase mortality in
young adults.
The urine is the most reliable test for arsenic
exposure within the last few days. Tests on hair and
fingernails can measure exposure to high levels of
arsenic onver the past 6-12 months. Arsenic may have an
affinity for hair. Thus hair samples may give falsely
elevated results. These tests can determine if you hae
been exposed to above-average levels of arsenic. They
cannot predict whether the arsenic levels in your body
will affect your health.
EPA has set the arsenic standard for drinking water at .010
parts per million (10 parts per billion) to protect consumers
served by public water systems from the effects of long-term,
chronic exposure to arsenic. Arsenic toxicity in the body can
increase with time and exposure. The rate of arsenic intake can
exceed the rate of elimination from the body.
Cardiovascular
Disease
Cardiovascular disease is the leading cause of death worldwide.
Chronic arsenic poisoning may be persistent and/or
irreversible. Arsenic induced cardiovascular disease may result
from the interaction among genetic, environment and nutritional
factors.
Chronic arsenic
poisoning through ingestion of arsenic-contaminated water is
associated with various cardiovascular diseases
including:
|
Atherosclerosis
|
High
blood pressure
|
Stroke
and Heart attack
|
|
Impaired
electrical conduction in the
heart
|
Peripheral
vascular disease (aka peripheral artery
disease)
|
Impaired
small blood vessel
circulation
|
World Health Organization Statements
·
Increased
risks of lung and bladder cancer and of arsenic-associated skin
lesions have been observed at drinking-water arsenic
concentrations of less than 0.05 mg/L.
·
Immediate
symptoms on an acute poisoning typically include vomiting,
esophagus and abdominal pain, and bloody "rice water"
diarrhea.
·
The
symptoms and signs that arsenic causes appear to differ between
individuals, population groups and geographic areas. Thus,
there is no universal definition of the disease caused by
arsenic.
·
Following
long-term exposure, the first changes are usually observed in
the skin: pigmentation changes, and then hyperkeratosis. Cancer
is a late phenomenon, and usually takes more than 10 years to
develop.
Skin
Absorption
Dermal absorption during
showering and hand washing can be an important exposure route
if the water contains more than 100 mcg/L As(III) or As(V).
Cell changes, cell death associated with disruption of the cell
membrane, and inhibition of DNA and protein syntheses occur at
As(III) exposure doses as low as 10 mcg/L. One to
6.4% of arsenic applied to the skin or during bathing is
absorbed and eliminated through the kidneys.
EPA standards for Arsenic Levels in Water
Health-based, non-enforceable Maximum Contaminant Level Goal
(MCGL) of 0.0.
Enforceable Maximum Contaminant Level (MCL) 0f 0.01 mg/ml
(10ug/L) (10mcg/L) (10ppb).
How to test your body for Arsenic Toxicity:
Comprehensive
Urine Element Profile
How to test water for Arsenic
Toxicity:
Recommended Arsenic Toxicity Water
Treatment: [9]
References
http://www.atsdr.cdc.gov/tfacts2.html
http://www.epa.gov/OGWDW/arsenic/
National
Toxicology Program
(http://ntp.niehs.nih.gov/)
Risk of
carotid atherosclerosis associated with genetic
polymorphisms of apolipoprotein E and inflammatory genes
among arsenic exposed residents in
Taiwan
.
Hsieh YC, Hsieh FI, Lien LM, Chou YL, Chiou HY, Chen
CJ. Toxicol Appl
Pharmacol. 2008 Feb 15;227(1):1-7.
A review
of the epidemiologic literature on the role of
environmental arsenic exposure and cardiovascular diseases.
Wang CH, Hsiao CK, Chen CL, Hsu LI, Chiou HY, Chen SY,
Hsueh YM, Wu MM, Chen CJ. Toxicol Appl
Pharmacol. 2007 Aug
1;222(3):315-26.
http://www.who.int/mediacentre/factsheets/fs210/en/index.html
World Health Organization
Effects
of arsenic on human keratinocytes: morphological,
physiological, and precursor incorporation
studies. Bernstam L,
Lan CH, Lee J, Nriagu JO. Environ Res. 2002
Jul;89(3):220-35.
In vivo and in vitro percutaneous absorption and
skin decontamination of arsenic from water and soil. Wester
RC, Maibach HI, Sedik L, Melendres J, Wade
M.
Fundam Appl Toxicol. 1993
Apr;20(3):336-40.
[9] National
Testing Laboratories Corrective Action
Brochure
Return from Arsenic
Toxicity and Arsenic Poisoning to Water Quality and
Toxicities.
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