The oxidative effects of ultraviolet A (UVA) light (320-400 nm) and the antioxidant effects of quercetin were examined. Oxidative stress is reflected by increased MDA and reduced antioxidant enzyme levels.

9. Kahraman, A.; Inal, M. E. JOURNAL NAME- J Appl Toxicol VOL. 22 2002 Sep-Oct PP. 303-9 DOCUMENT TYPE- Journal Article JOURNAL CODE- 8109495 ISSN- 0260-437X CORPORATE AUTHOR- Department of Biochemistry, The Medical School, Afyon Kocatepe University, Afyon-03200, Turkey. ahmetkah@aku.edu.tr PUBLICATION COUNTRY- England LANGUAGE- English The oxidative effects of ultraviolet A (UVA) light (320-400 nm) and the antioxidant effects of quercetin were examined in rat blood. For this purpose, rats were divided into three groups: control, ultraviolet (UV) and ultraviolet + quercetin (UV + Q). The UV and UV+ Q groups were irradiated for 4 h a day with UVA light (1.25 mW cm(2)) during periods of 3, 6 and 9 days. Quercetin (50 mg kg(-1) body wt.) was administered intraperitoneally in the UV + Q group rats before irradiation periods. Blood was taken 3, 6 and 9 days post-treatment. Plasma malondialdehyde ( MDA ) levels significantly increased after 9 days of daily exposure to UVA. Whole blood glutathione (GSH) levels significantly declined after 3-9 days of irradiation. Glutathione peroxidase activity on days 6 and 9 and glutathione reductase activities on days 3, 6 and 9 post-irradiation were diminished significantly. Superoxide dismutase and catalase activities decreased significantly 3-9 days post-irradiation. The administration of quercetin before the 9-day period of irradiation significantly reduced the increase in plasma MDA value. Whole blood GSH levels significantly decreased with the administration of quercetin on all days. Quercetin significantly increased antioxidant enzymes diminished by UVA irradiation. Exposure of rats to UVA light leads to oxidative stress, reflected by increased MDA and reduced antioxidant enzyme levels. The administration of quercetin appears to be a useful approach to reduce the damage produced by UVA radiation.; Copyright 2002 John Wiley 38 Sons, Ltd.

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