Oxidative stress status was determined by measuring the concentration of urinary malondialdehyde ( MDA ) … Since the measurement of MDA in urine gives a 'global' index of the body's oxidative stress status.

6. Gupta, Pratibha; Gambhir, J. K.; Natarajan, Sujata; Singh, Savita JOURNAL NAME- Biomedical Research (Aligarh) VOL. 12 NO. 3 September-December, 2001 PP. 231-236. DOCUMENT TYPE- Article ISSN- 0970-938X ADDRESS- E-14, GTB Hospital Campus, Dilshad Garden, Delhi, 110095, India LANGUAGE- ENGLISH Oxidative stress status was determined by measuring the concentration of urinary malondialdehyde ( MDA ) in 80 males grouped as electroplaters (40) and non-electroplaters (40) drawn from electroplating and non-electroplating units respectively, of East Delhi factories. The concentration of MDA in urine was estimated by measuring thiobarbituric acid reactive substances by the spectrophotometric method. Creatinine concentration of the urine sample was measured by Jaffe's method. The results were presented as nmoles of MDA per mg of creatinine. Many occupational substances including metals, damage tissues by the generation of free radicals. We found a higher level of urinary MDA in electroplaters as compared to non-electroplaters and the values were statistically significant. Since the measurement of MDA in urine gives a 'global' index of the body's oxidative stress status, our results suggest that there is increased oxidative stress in electroplaters as compared to non-electroplaters.

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